Anti-Phospho-CREB (S133) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Rabbit
Accession Number	P16220
Gene Id	1385
Gene Symbols	CREB1
Protein Name / Synonyms	Phospho-CREB(S133)
Clonality	Polyclonal
Preparation	This CREB Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S133 of human CREB.
Concentration (lot specific)	0.360 mg/ml
Recommended Applications	Western Blotting, IHC-P
Research Area	Cancer, Inflammation
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

CREB is a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, (CRE), a sequence present in many viral and cellular promoters. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway.

Specificity

Other Names

CREB1; Cyclic AMP-responsive element-binding protein 1

NCBI Accession #

NP_004370.1;NP_604391.1

Format

Type

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

36688

Recommended Dilutions

WB: 1:1000; IHC: 1:50-100

	Western blot analysis of anti-Phospho-CREB-pS133 Pab (Cat# 102-15294) in CEM cell line tissue lysate (35ug/lane).Phospho-CREB-pS133(arrow) was detected using the purified Pab.
	Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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