Anti-Phospho-CRK (S41) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Rabbit
Accession Number	P46108
Gene Id	1398
Gene Symbols	CRK
Protein Name / Synonyms	Phospho-CRK(S41)
Clonality	Polyclonal
Preparation	This CRK Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S41 of human CRK.
Concentration (lot specific)	0.445 mg/ml
Recommended Applications	Dot Blotting
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

CRK is a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. It has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation.

Specificity

Predicted Reactivity

Mouse, Rat

Other Names

CRK; Adapter molecule crk; Proto-oncogene c-Crk; p38

NCBI Accession #

NP_005197.3;NP_058431.2

Other Accession #

Q63768; Q64010; Q96GA9

Format

Type

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

33831

Recommended Dilutions

DB: 1:500

Dot blot analysis of Phospho-CRK-S41 polyclonal antibody (Cat# 102-15378) on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentration was 0.5ug per ml. P-Pab: phospho-antibody; P-Peptide: phospho-peptide; NP-Peptide: non-phospho-peptide.

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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