Anti-Phospho-EIF4EBP1 (T36) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Rabbit
Accession Number	Q13541
Gene Id	1978
Gene Symbols	EIF4EBP1
Protein Name / Synonyms	Phospho-EIF4EBP1(T36)
Clonality	Polyclonal
Preparation	This EIF4EBP1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T36 of human EIF4EBP1.
Concentration (lot specific)	0.5 mg/ml
Recommended Applications	Dot Blotting
Research Area	mTOR Signaling
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

EIF4EBP1 is a member of a family of translation repressor proteins. This protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. It is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation.

Specificity

Predicted Reactivity

Mouse, Rat, Bovine

Other Names

EIF4EBP1; Eukaryotic translation initiation factor 4E-binding protein 1; Phosphorylated heat- and acid-stable protein regulated by insulin 1

NCBI Accession #

NP_004086.1

Other Accession #

Q62622; Q60876; Q0P5A7; NP_004086

Format

Type

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

12580

Recommended Dilutions

DB: 1:500

Dot blot analysis of anti-EIF4EBP1-pT36 Phospho-specific Pab (Cat#AP3416a) on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.5ug per ml.

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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