Anti-Phospho-EP300 (S1834) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Rabbit
Accession Number	Q09472
Gene Id	2033
Gene Symbols	EP300
Protein Name / Synonyms	Phospho-EP300(S1834)
Clonality	Polyclonal
Preparation	This EP300 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S1834 of human EP300.
Concentration (lot specific)	0.490 mg/ml
Recommended Applications	Dot Blotting
Research Area	Cardiovascular Disease, Cancer, Autophagy
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer.

Specificity

Other Names

EP300; P300; Histone acetyltransferase p300; E1A-associated protein p300

NCBI Accession #

NP_001420.2

Other Accession #

NP_001420.2

Format

Type

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

264161

Recommended Dilutions

DB: 1:500

Dot blot analysis of EP300 Antibody (Phospho S1834) Phospho-specific Pab (Cat# 102-15699) on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.6ug per ml.

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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