3607 Parkway Ln Ste 200 Norcross, Georgia 30092
www.RayBiotech.com | info@raybiotech.com
770-729-2992 | +1-888-494-8555
ISO 13485:2016 cGMP
Anti-Phospho-INSR (Y1185) Antibody
Catalog #: 102-15472
Rabbit Anti-Human Phospho-INSR(Y1185) Antibody, 400 ul
Product Description
Specifications
| Size | 400 µL |
| Estimated Lead Time | 1-2 weeks |
| Species | Human |
| Host Species | Rabbit |
| Accession Number | P06213 |
| Gene Id | 3643 |
| Gene Symbols | INSR |
| Protein Name / Synonyms | Phospho-INSR(Y1185) |
| Clonality | Polyclonal |
| Preparation | This INSR Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y1185 of human INSR. |
| Concentration (lot specific) | 0.5 mg/ml |
| Recommended Applications | Dot Blotting |
| Research Area | Cardiovascular Disease |
| Shipping Type | Blue ice |
| Storage | -20°C |
Description
Introduction
Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake, thereby mediating the metabolic functions of insulin. Binding to insulin stimulates association of the receptor with downstream mediators including IRS1 and phosphatidylinositol 3'-kinase (PI3K). This protein can activate PI3K either directly by binding to the p85 regulatory subunit, or indirectly via IRS1. After removal of the precursor signal peptide, the insulin receptor precursor is post-translationally cleaved into two chains (alpha and beta) that are covalently linked.
Specificity
Predicted Reactivity
Mouse, Rat, Bovine, Drosophila, Xenopus
Other Names
INSR; Insulin receptor; CD_antigen=CD220; Insulin receptor subunit alpha; Insulin receptor subunit beta
NCBI Accession #
NP_000199.2;NP_001073285.1
Other Accession #
Q9PVZ4; P15127; P15208; P09208; O73798; P24062; Q60751; P08069; Q05688
Format
Type
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Calculated Molecular Weight (Da)
156333
Recommended Dilutions
DB: 1:500
 | Dot blot analysis of anti-Phospho-INSR-pY1185 Antibody (Cat# 102-15472) on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.5ug per ml. |
Antigen Source
HUMAN
Storage/Stability
2-8°C (short-term); -20°C (long-term)
Expiration:
12 months from the date of shipment when stored properly.