Anti-Phospho-p27Kip1 (T170) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Rabbit
Accession Number	P46527
Gene Id	1027
Gene Symbols	CDKN1B
Protein Name / Synonyms	Phospho-p27Kip1(T170)
Clonality	Polyclonal
Preparation	This p27Kip1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T170 of human p27Kip1.
Concentration (lot specific)	0.5 mg/ml
Recommended Applications	Dot Blotting
Research Area	Cardiovascular Disease, Cancer, Autophagy
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. [provided by RefSeq].

Specificity

Predicted Reactivity

Mouse, Hamster

Other Names

CDKN1B; KIP1; Cyclin-dependent kinase inhibitor 1B; Cyclin-dependent kinase inhibitor p27; p27Kip1

NCBI Accession #

NP_004055.1

Other Accession #

P46414; Q60439; NP_004055.1

Format

Type

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

22073

Recommended Dilutions

DB: 1:500

Dot blot analysis of p27Kip1 Antibody (Phospho T170) Phospho-specific Pab (Cat# 102-15723) on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.6ug per ml.

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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