Anti-Phospho-PTEN (Y315) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Rabbit
Accession Number	P60484
Gene Id	5728
Gene Symbols	PTEN
Protein Name / Synonyms	Phospho-PTEN(Y315)
Clonality	Polyclonal
Preparation	This PTEN Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y315 of human PTEN.
Concentration (lot specific)	0.430 mg/ml
Recommended Applications	Dot Blotting
Research Area	Cardiovascular Disease, Cancer, Akt Signaling
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway.

Specificity

Predicted Reactivity

Mouse

Other Names

PTEN; MMAC1; TEP1; Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN; Mutated in multiple advanced cancers 1; Phosphatase and tensin homolog

NCBI Accession #

NP_000305.3

Other Accession #

O08586; NP_000305.3

Format

Type

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

47166

Recommended Dilutions

DB: 1:500

Dot blot analysis of PTEN Antibody (Phospho Y315) Phospho-specific Pab (Cat# 102-15708) on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.6ug per ml.

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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