3607 Parkway Ln Ste 200 Norcross, Georgia 30092
www.RayBiotech.com | info@raybiotech.com
770-729-2992 | +1-888-494-8555
ISO 13485:2016 cGMP
Anti-Phospho-RB-S795 Antibody
Catalog #: 144-50645
Phospho-RB-S795 pAb
Product Description
Specifications
| Size | 20 µL, 100 µL |
| Estimated Lead Time | 1-2 weeks |
| Species | Human, Mouse, Rat |
| Host Species | Rabbit |
| Accession Number | P06400 |
| Gene Id | 5925 |
| Gene Symbols | RB1 |
| Protein Name / Synonyms | RB1, OSRC, PPP1R130, RB, p105-Rb, pRb, pp110, RB transcriptional corepressor 1 |
| Isotype | IgG |
| Purity | Affinity purification |
| Buffers | PBS with 0.02% sodium azide, 50% glycerol, pH7.3 |
| Recommended Applications | Western Blotting, IF |
| Research Area | Cancer, Inflammation |
| Shipping Type | Blue ice |
| Storage | -20°C |
Description
Background
The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.
Dilutions
WB 1:500 - 1:1000; IF 1:50 - 1:100
Format
Calculated MW
106kDa
Observed MW
106kDa
Immunogen
A synthetic phosphorylated peptide around S795 of human RB (NP_000312.2).
Modification
Phospho S795
Storage
Store at -20°. Avoid freeze / thaw cycles.
Images
Expiration:
12 months from the date of shipment when stored properly.