Anti-Phospho-RPS6KB1 (S418) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Rabbit
Accession Number	P23443
Gene Id	6198
Gene Symbols	RPS6KB1
Protein Name / Synonyms	Phospho-RPS6KB1(S418)
Clonality	Polyclonal
Preparation	This RPS6KB1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S418 of human RPS6KB1.
Concentration (lot specific)	0.350 mg/ml
Recommended Applications	Dot Blotting
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates several residues of the S6 ribosomal protein. The kinase activity of this protein leads to an increase in protein synthesis and cell proliferation. Amplification of the region of DNA encoding this gene and overexpression of this kinase are seen in some breast cancer cell lines. Alternate translational start sites have been described and alternate transcriptional splice variants have been observed but have not been thoroughly characterized.

Specificity

Predicted Reactivity

Mouse, Rat, Bovine, Rabbit

Other Names

RPS6KB1; STK14A; Ribosomal protein S6 kinase beta-1; 70 kDa ribosomal protein S6 kinase 1; Ribosomal protein S6 kinase I; Serine/threonine-protein kinase 14A; p70 ribosomal S6 kinase alpha

NCBI Accession #

NP_001258989.1;NP_003152.1

Other Accession #

P67999; P67998; Q8BSK8; Q6TJY3

Format

Type

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

59140

Recommended Dilutions

DB: 1:500

Dot blot analysis of anti-RPS6KB1-pS418 Phospho-specific Pab (Cat# 102-15397) on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.5ug per ml.

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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