Anti-Phospho-TSC1 (S505) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Rabbit
Accession Number	Q92574
Gene Id	7248
Gene Symbols	TSC1
Protein Name / Synonyms	Phospho-TSC1(S505)
Clonality	Polyclonal
Preparation	This TSC1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S505 of human TSC1.
Concentration (lot specific)	0.35 mg/ml
Recommended Applications	Dot Blotting
Research Area	Cardiovascular Disease, Autophagy
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

TSC1 is implicated as a tumor suppressor, and may have a function in vesicular transport. Interaction between TSC1 and TSC2 may facilitate vesicular docking. Defects in TSC1 are the cause of tuberous sclerosis complex (TSC). The molecular basis of TSC is a functional impairement of the hamartin-tuberin complex. TSC is an autosomal dominant multi-system disorder that affects especially the brain, kidneys, heart, and skin. Defects in TSC1 may be a cause of focal cortical dysplasia of Taylor balloon cell type (FCDBC). FCDBC is a subtype of cortical displasias linked to chronic intractable epilepsy. Cortical dysplasias display a broad spectrum of structural changes, which appear to result from changes in proliferation, migration, differentiation, and apoptosis of neuronal precursors and neurons during cortical development.

Specificity

Predicted Reactivity

Mouse

Other Names

TSC1; KIAA0243; TSC; Hamartin; Tuberous sclerosis 1 protein

NCBI Accession #

NP_000359.1;NP_001155898.1;NP_001155899.1

Other Accession #

Q9EP53

Format

Type

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

129767

Recommended Dilutions

DB: 1:500

Dot blot analysis of anti-TSC1-pS505 Phospho-specific Pab (RB13337) on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.5ug per ml.

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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