Anti-Phospho-TSC2 (S939) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Rabbit
Accession Number	P49815
Gene Id	7249
Gene Symbols	TSC2
Protein Name / Synonyms	Phospho-TSC2(S939)
Clonality	Polyclonal
Preparation	This TSC2 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S939 of human TSC2.
Concentration (lot specific)	0.5 mg/ml
Recommended Applications	IF, Dot Blotting
Research Area	Cardiovascular Disease, Autophagy
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

Mutations in TSC2 lead to tuberous sclerosis complex. The protein is believed to be a tumor suppressor and is able to specifically stimulate the intrinsic GTPase activity of the Ras-related protein RAP1A and RAB5. The protein associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. TSC2 may have a function in vesicular transport, but may also play a role in the regulation of cell growth arrest and in the regulation of transcription mediated by steroid receptors. Interaction between TSC1 and TSC2 may facilitate vesicular docking.

Specificity

Predicted Reactivity

Mouse

Other Names

TSC2; TSC4; Tuberin; Tuberous sclerosis 2 protein

NCBI Accession #

NP_000539.2;NP_001070651.1;NP_001107854.1

Other Accession #

Q61037

Format

Type

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

200608

Recommended Dilutions

DB: 1:500; IF: 1:10-50

	Dot blot analysis of anti-TSC2-pS939 Phospho-specific Pab (Cat.102-15416) on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.5ug per ml.
	Confocal immunofluorescent analysis of Phospho-TSC2-pS939 Antibody(Cat# 102-15416) with MCF-7 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green).Actin filaments have been labeled with Alexa Fluor 555 phalloidin (red).DAPI was used to stain the cell nuclear (blue).

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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