Anti-PID/MTA2 (C-term) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human, Mouse
Host Species	Rabbit
Accession Number	O94776
Gene Id	9219
Gene Symbols	MTA2
Protein Name / Synonyms	PID/MTA2 (C-term)
Clonality	Polyclonal
Preparation	This PID/MTA2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 516-544 amino acids from the C-terminal region of human PID/MTA2.
Concentration (lot specific)	2.0 mg/ml
Recommended Applications	Western Blotting, IHC-P, FC
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

MTA2 is a protein that has been identified as a component of NuRD, a nucleosome remodeling deacetylase complex identified in the nucleus of human cells. It shows a very broad expression pattern and is strongly expressed in many tissues. It may represent one member of a small family of different but related proteins involved either directly or indirectly in transcriptional regulation. Their indirect effects on transcriptional regulation may include chromatin remodeling. It is closely related to another member of this family, a protein that has been correlated with the metastatic potential of certain carcinomas. These two proteins are so closely related that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. One of the proteins known to be a target protein for this gene product is p53. Deacteylation of p53 is correlated with a loss of growth inhibition in transformed cells supporting a connection between these gene family members and metastasis.

Specificity

Other Names

MTA2; MTA1L1; PID; Metastasis-associated protein MTA2; Metastasis-associated 1-like 1; p53 target protein in deacetylase complex

NCBI Accession #

NP_004730.2

Other Accession #

Q9R190

Format

Type

Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

75023

Recommended Dilutions

WB: 1:1000; IHC: 1:50-100; FC: 1:10-50

	PID/MTA2 Antibody (C-term) (Cat# 102-16876) western blot analysis in Hela cell line and mouse brain tissue lysates (35ug/lane).This demonstrates the PID/MTA2 antibody detected the PID/MTA2 protein (arrow).
	Formalin-fixed and paraffin-embedded human brain tissue reacted with PID/MTA2 Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
	Flow cytometric analysis of hela cells using PID/MTA2 Antibody (C-term)(bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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