The Class III PI3K (phosphoinositide 3-kinase), Vps34 (vacuolar protein sorting 34), was first identified in yeast, then it was also defined in mammalian cells of different species, including human, designated as hVPS34. Investigations shown that it could play an important role in the ability of cells to respond to changes in nutrient conditions. In both yeast and mammalian cells, Class III PI3Ks are also required for the induction of autophagy during nutrient deprivation. Finally, mammalian hVPS34 is itself regulated by nutrients. Thus Class III PI3Ks are implicated in the regulation of both autophagy and, through the mTOR pathway, protein synthesis, and thus contribute to the integration of cellular responses to changing nutritional status.

The antibody is stable for at least 1 year from the date of receipt when stored at -20°C to -70°C. Reconstituted antibody can also be aliquotted and stored at 4°C for 1 month or at -20°C to -70°C in a manual defrost freezer for many months without detectable loss activity. Please avoid freeze-thaw cycles.

The rabbit anti-human hVPS34 antibody detects specifically synthetic antigen derived from human hVPS34 at various concentrations. Reactivity with cellular proteins is not tested yet. Cross reactivity with other species are expected from sequence similarity.