Anti-PINK1 (PARK6) (Center) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human, Mouse
Host Species	Rabbit
Accession Number	Q9BXM7
Gene Id	65018
Gene Symbols	PINK1
Protein Name / Synonyms	PINK1 (PARK6) (Center)
Clonality	Polyclonal
Preparation	This PINK1 (PARK6) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 237-266 amino acids from the Central region of human PINK1 (PARK6).
Concentration (lot specific)	2.0 mg/ml
Recommended Applications	Western Blotting
Research Area	Autophagy
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

Parkinson is the second most common neurodegenerative disease after Alzheimers. About 1 percent of people over the age of 65 and 3 percent of people over the age of 75 are affected by the disease. The mutation is the most common cause of Parkinson disease identified to date. Defects in PINK1 are the cause of autosomal recessive early-onset Parkinson's disease 6 (PARK6). Six novel pathogenic PINK1 mutations suggest that PINK1 may be the second most common causative gene next to parkin in parkinsonism with the recessive mode of inheritance. Strong evidence indicates that, although important in mendelian forms of Parkinson's disease (PD), PINK1 does not influence the cause of sporadic nonmendelian forms of PD.

Specificity

Other Names

PINK1; Serine/threonine-protein kinase PINK1, mitochondrial; BRPK; PTEN-induced putative kinase protein 1

NCBI Accession #

NP_115785.1

Other Accession #

NP_115785

Format

Type

Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

62769

Recommended Dilutions

WB: 1:1000

	The anti-PINK1 C-term Pab (Cat# 102-16772) is used in Western blot to detect PINK1 in mouse heart tissue lysate.
	Park6 (PINK1) Antibody (Center) (Cat# 102-16772) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the Park6 (PINK1) antibody detected the Park6 (PINK1) protein (arrow).

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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