Anti-PLK2 (SNK) (C-term) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human, Mouse, Rat
Host Species	Rabbit
Accession Number	Q9NYY3
Gene Id	10769
Gene Symbols	PLK2
Protein Name / Synonyms	PLK2 (SNK) (C-term)
Clonality	Polyclonal
Preparation	This PLK2 (SNK) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 375-406 amino acids from the C-terminal region of human PLK2 (SNK).
Concentration (lot specific)	0.500 mg/ml
Recommended Applications	Western Blotting, IHC-P
Research Area	Angiogenesis, Inflammation, Autophagy
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

Plks (polo-like kinases) encode serine/threonine kinases that are closely related to polo and CDC5, genes that are required for passage through mitosis in Drosophila and Saccharomyces, respectively. Polo-like kinases, which include Plk, Snk (for serum-inducible kinase, also designated Plk2) and Fnk (for FGF-inducible kinase, also designated Plk3 or PRK), play a role in cell proliferation. Plk protein accumulates in the cell during S and G2 phases of the cell cycle, and both protein content and catalytic activity peak at the onset of mitosis, followed by a rapid reduction after mitosis. Snk and Fnk are immediate-early response genes that are first expressed during G1 phase. SNK may play a role in the division of at least some cell types, such as fibroblasts, and could function in embryogenesis, wound healing or neoplasia SNK mRNA is rapidly induced in human lung fibroblasts upon reintroduction of serum following 36 hours of serum deprivation.

Specificity

Other Names

PLK2; SNK; Serine/threonine-protein kinase PLK2; Polo-like kinase 2; Serine/threonine-protein kinase SNK; Serum-inducible kinase

NCBI Accession #

NP_001239155.1;NP_006613.2

Other Accession #

Q9R012

Format

Type

Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

78237

Recommended Dilutions

WB: 1:1000; IHC: 1:50-100

	The anti-SNK C-term Pab (Cat# 102-17213) is used in Western blot to detect SNK in PMA-treated Pam212 cell lysate (lane 1) and rat testis tissue lysate (lane 2).
	Formalin-fixed and paraffin-embedded human breast carcinoma tissue reacted with SNK Antibody (C-term ) (Cat# 102-17213), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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