Anti-PPAR alpha (N-term) Antibody

Catalog #: DS-PB-02732

Rabbit Anti-Human PPAR alpha (N-term)

Product Description

Specifications

Size	50 µg
Estimated Lead Time	1-2 weeks
Species	Human
Specificity	This product detects an epitope within the N-terminal region of human peroxisome proliferator-activated receptor, alpha (PPARA), a member of the nuclear hormone receptor subfamily. Upon activation, PPARA forms heterodimers with retinoid X receptors (RXRs), and functions to regulate transcription of specific gene sequences. In particular, PPARA controls genes involved in the peroxisomal and mitochondrial beta oxidation pathways, fatty acid uptake, and triglyceride catabolism in the liver and skeletal muscle. PPARA also has anti-inflammatory and anti-proliferative effects and prevents the proatherogenic effects of cholesterol accumulation in macrophages by stimulating cholesterol efflux. PPARA is the main target of fibrate drugs; hypolipidemic agents used in the treatment of dyslipidemia and the prevention of cardiovascular disease. They could also be used for the treatment of type II diabetes.
Host Species	Rabbit
Protein Name / Synonyms	PPAR alpha
Preparation	Antisera to human PPAR alpha were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared from whole serum by affinity chromatography.
Concentration (lot specific)	IgG concentration 1.0mg/ml
Recommended Applications	ELISA (dilution: 1/500, 1/1000), Western Blotting
Research Area	PPAR Signaling
Shipping Type	Blue ice
Storage	-20°C

Description

This product detects a band of approximately 52kDa in 3T3 whole cell lysate.

Storage/Stability

Store at +4 °C or at -20 °C if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 18 months after receipt.

Format

Supplied as:

Purified IgG - liquid

Formulation:

Phosphate buffered saline

Format Type:

Purified

Preparation

Antisera to human PPAR alpha were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared from whole serum by affinity chromatography.

Immunogen:

Synthetic peptide corresponding to amino acids 1-18 of human PPAR alpha.

Preservative:

0.09%

Sodium Azide (NaN₃)

Expiration:

12 months from the date of shipment when stored properly.

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