Anti-PPM1A Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Rabbit
Accession Number	P35813
Gene Id	5494
Gene Symbols	PPM1A
Protein Name / Synonyms	PPM1A
Clonality	Polyclonal
Preparation	This PPM1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 355-382 amino acids from human PPM1A.
Concentration (lot specific)	0.270 mg/ml
Recommended Applications	Western Blotting
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described.

Specificity

Predicted Reactivity

Bovine, Rabbit

Other Names

PPM1A; PPPM1A; Protein phosphatase 1A; Protein phosphatase 2C isoform alpha; Protein phosphatase IA

NCBI Accession #

NP_066283.1;NP_808820.1;NP_808821.2

Other Accession #

P35814; O62829; NP_066283.1; NP_808820.1

Format

Type

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

42448

Recommended Dilutions

WB: 1:1000

PPM1A Antibody (pS) (Cat# 102-12424) western blot analysis in SK-BR-3 cell line lysates (35ug/lane).This demonstrates the PPM1A antibody detected the PPM1A protein (arrow).

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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