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Anti-PRL3 Antibody
Catalog #: 102-17874
Rabbit Anti-PRL3 Antibody, 400 ul
Product Description
Specifications
| Size | 400 µL |
| Estimated Lead Time | 1-2 weeks |
| Species | Human, Mouse |
| Host Species | Rabbit |
| Accession Number | O75365 |
| Gene Id | 11156 |
| Gene Symbols | PTP4A3 |
| Protein Name / Synonyms | PRL3 |
| Clonality | Polyclonal |
| Preparation | This PRL3 antibody is generated from rabbits immunized with a recombinant protein encoding full length of human PRL3. |
| Concentration (lot specific) | 2.0 mg/ml |
| Recommended Applications | Western Blotting |
| Shipping Type | Blue ice |
| Storage | -20°C |
Description
Introduction
The protein encoded by this gene belongs to a small class of prenylated protein tyrosine phosphatases (PTPs). PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. This class of PTPs contain a PTP domain and a characteristic C-terminal prenylation motif. Studies of this class of PTPs in mice demonstrated that they were prenylated proteins in vivo, which suggested their association with cell plasma membrane. Overexpression of this gene in mammalian cells was reported to inhibit angiotensin-II induced cell calcium mobilization and promote cell growth. Two alternatively spliced variants exist. PRL-3 expression was found to be up-regulated in human liver carcinoma compared with normal liver. Its expression in colorectal cancers may contribute to the establishment of liver metastasis. In a different study, PRL-3 is found to be expressed in tumor metastasis and vasculature, regardless of the tumor source.
Specificity
Other Names
PTP4A3; PRL3; Protein tyrosine phosphatase type IVA 3; PRL-R; Protein-tyrosine phosphatase 4a3; Protein-tyrosine phosphatase of regenerating liver 3
NCBI Accession #
NP_009010.2;NP_116000.1
Other Accession #
NP_116000
Format
Type
Purified Rabbit Polyclonal Antibody (Pab)
Calculated Molecular Weight (Da)
19535
Recommended Dilutions
WB: 1:1000
 | Western blot analysis of PRL3 Antibody (Cat# 102-17874) in mouse heart tissue lysates (35ug/lane). PRL3 (arrow) was detected using the purified Pab. |
Antigen Source
HUMAN
Storage/Stability
2-8°C (short-term); -20°C (long-term)
Expiration:
12 months from the date of shipment when stored properly.