Anti-Prostate Apoptosis Response protein-4 Antibody

Product Description

Specifications

Size	100 µL
Estimated Lead Time	1-2 weeks
Species	Human, Mouse, Rat
Host Species	Rabbit
Accession Number	Q96IZ0
Gene Id	5074
Gene Symbols	PAWR
Protein Name / Synonyms	Prostate Apoptosis Response protein-4
Clonality	Polyclonal
Recommended Applications	Western Blotting, IHC
Research Area	Apoptosis, Cancer
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

Pro-apoptopic protein capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappa-B transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down- regulates the anti-apoptotic protein BCL2 via its interaction with WT1. Seems also to be a transcriptional repressor by itself. May be directly involved in regulating the amyloid precursor protein (APP) cleavage activity of BACE1.

Specificity

Other Names

PRKC apoptosis WT1 regulator protein, Prostate apoptosis response 4 protein, Par-4, PAWR, PAR4

Format

Type

Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

36568

Recommended Dilutions

WB: 1:1000

Western blot analysis of lysate from SW620 cell line,using Prostate Apoptosis Response protein-4 Antibody(C0309). C0309 was diluted at 1:1000. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody.Lysate at 35ug.

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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