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Anti-PST Antibody
Catalog #: 130-10092
Rabbit Anti-Human PST Antibody
Product Description
Specifications
| Size | 20 µg, 100 µg, 200 µg, 500 µg |
| Estimated Lead Time | 1-2 business days |
| Species | Human |
| Accession Number | P07492 |
| Gene Id | 2922 |
| Gene Symbols | GRP |
| Clonality | Polyclonal |
| Immunogen | Immunogen was synthetic peptide derived from human Pancreastatin. This antibody was produced from a rabbit immunized with the immunogen. The IgG fraction was purified from rabbit serum followed by Protein A/G affinity chromatography. |
| Immunogen Sequence | CDGAGKPGAEEAQDPEGKGEQEHS |
| Recommended Applications | ELISA (recommended work dilution= 1: 80, 000) |
| Reconstitution | Product is supplied as a powder obtained from lyophilization of purified antibody in PBS without preservatives. Reconstitute the antibody with sterile water to a final concentration of 1 mg/ml. |
| Shipping Type | Ambient temperature |
| Storage | -20°C |
Description
Description
Pancreastatin is a 49 amino acid peptide produced by degradation of Chromo-granin A. It inhibits Chromogranin A and Parathyroid Hormone release. Pancreastatin also inhibits release of Somatostatin upon glucose stimulation. It may also control carbohydrate metabolism and hyperglycemia. Although there are no compounds with significant structural homology with Pancreastatin, there are minor similarities to Gastrin and Anti-Diuretic Hormone. Pancreastatin reduces the the early phase of Glucose induced Insulin release. Suppression of Insulin release upon Glucose stimulation is a characteristic feature of Type II Diabetes. Pancreastatin could play an important therapeutic role in the treatment of diabetes. Pancreastatin also inhibits release of Somatostatin. It may also control carbohydrate metabolism and hyperglycemia.
Specificity
The antibody binds to human Pancreastatin. Cross reactivity with mouse or rat Pancreastatin was not tested.
Storage
Store at 4°C if intended for use within one month, otherwise, store at -20°C to -80°C. The lyophilized antibody is stable for at least 18 months after the date of receipt when stored at -20°C to -80°C. After reconstitution, it can also be aliquoted and stored frozen at -20°C to -80°C in a manual defrost freezer for at least 6 months without detectable loss of activity. Upon reconstitution, the antibody can also be stored for 30 days at 4°C. Please avoid freeze-thaw cycles, as this will lower the activity of the antibody.
Related Products
RayBio® Pancreastatin EIA Kit (cat#EIA-PAN-1)
References
- González-Yanes C; et al. (2001) Pancreastatin, a chromogranin A-derived peptide, activates Galpha(16) and phospholipase C-beta(2) by interacting with specific receptors in rat heart membranes. Cell Signal. 2001 Jan;13(1):43-9.
- Piero, E. et al. (1989) Pancreastatin Inhibits Insulin Secretion as Induced by Glucagon, Vasoactive Intestinal Polypeptide, Gastric Inhibiting Peptide, and 8-Cholecystokinin in the Perfused Rat. Pancreas. Metabolism 38: 679-682.
- Tatemoto, K. et al. (1986) Pancreastatin, A Novel Pancreatic Peptide that Inhibits Insulin Secretion. Nature 324: 476-478.
Expiration:
12 months from the date of shipment when stored properly.