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Anti-PST Antibody, Biotinylated
Catalog #: 130-10092B-50
Rabbit anti-PST Biotinylated Antibody, 50 ug
Product Description
Specifications
| Size | 50 µg |
| Estimated Lead Time | 1-2 business days |
| Species | Human |
| Host Species | Rabbit |
| Accession Number | P07492 |
| Gene Id | 2922 |
| Gene Symbols | GRP |
| Clonality | Polyclonal |
| Immunogen | Immunogen was synthetic peptide derived from human Pancreastatin. This antibody was produced from a rabbit immunized with the immunogen. The IgG fraction was purified from rabbit serum followed by Protein A/G affinity chromatography. |
| Immunogen Sequence | CDGAGKPGAEEAQDPEGKGEQEHS |
| Isotype | IgG |
| Recommended Applications | ELISA (recommended work dilution= 1: 80, 000) |
| Reconstitution | A separate vial of dilution buffer is provided for reconstitution. The antibody is supplied lyophilized, originally containing PBS, without preservative stabilizers (e.g. sodium azide). The final amount is indicated on the shipping vial. |
| Shipping Type | Ambient temperature |
| Storage | -20°C |
Description
Description
Pancreastatin is a 49 amino acid peptide produced by degradation of Chromo-granin A. It inhibits Chromogranin A and Parathyroid Hormone release. Pancreastatin also inhibits release of Somatostatin upon glucose stimulation. It may also control carbohydrate metabolism and hyperglycemia. Although there are no compounds with significant structural homology with Pancreastatin, there are minor similarities to Gastrin and Anti-Diuretic Hormone. Pancreastatin reduces the the early phase of Glucose induced Insulin release. Suppression of Insulin release upon Glucose stimulation is a characteristic feature of Type II Diabetes. Pancreastatin could play an important therapeutic role in the treatment of diabetes. Pancreastatin also inhibits release of Somatostatin. It may also control carbohydrate metabolism and hyperglycemia.
Storage / Stability
The antibody is stable for at least 1 year from the date of receipt when stored at -20°C to -70°C. Reconstituted antibody can also be aliquotted and stored at 4°C for 1 month or at -20°C to -70°C in a manual defrost freezer for many months without detectable loss activity. Please avoid freeze-thaw cycles.
Specificity
The antibody binds to human Pancreastatin. Cross reactivity with mouse or rat Pancreastatin was not tested.
Related Products
RayBio® Pancreastatin EIA Kit (cat#EIA-PAN-1)
References
- Gonz¡lez-Yanes C; et al. (2001) Pancreastatin, a chromogranin A-derived peptide, activates Galpha(16) and phospholipase C-beta(2) by interacting with specific receptors in rat heart membranes. Cell Signal. 2001 Jan;13(1):43-9.
- Piero, E. et al. (1989) Pancreastatin Inhibits Insulin Secretion as Induced by Glucagon, Vasoactive Intestinal Polypeptide, Gastric Inhibiting Peptide, and 8-Cholecystokinin in the Perfused Rat. Pancreas. Metabolism 38: 679-682.
- Tatemoto, K. et al. (1986) Pancreastatin, A Novel Pancreatic Peptide that Inhibits Insulin Secretion. Nature 324: 476-478.
Expiration:
12 months from the date of shipment when stored properly.