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Anti-PTEN (Center T383/T382) Antibody
Catalog #: 102-13932
Rabbit Anti-Human PTEN (Center T383/T382) Antibody, 400 ul
Product Description
Specifications
| Size | 400 µL |
| Estimated Lead Time | 1-2 weeks |
| Species | Human |
| Host Species | Rabbit |
| Accession Number | P60484 |
| Gene Id | 5728 |
| Gene Symbols | PTEN |
| Protein Name / Synonyms | PTEN (Center T383/T382) |
| Clonality | Polyclonal |
| Preparation | This PTEN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 361-390 amino acids from the Central region of human PTEN. |
| Concentration (lot specific) | 0.300 mg/ml |
| Recommended Applications | Western Blotting |
| Research Area | Cardiovascular Disease, Cancer, Akt Signaling |
| Shipping Type | Blue ice |
| Storage | -20°C |
Description
Introduction
This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway.
Specificity
Predicted Reactivity
Mouse, Xenopus
Other Names
PTEN; MMAC1; TEP1; Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN; Mutated in multiple advanced cancers 1; Phosphatase and tensin homolog
NCBI Accession #
NP_000305.3
Other Accession #
Q9PUT6; O08586; NP_000305.3
Format
Type
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Calculated Molecular Weight (Da)
47166
Recommended Dilutions
WB: 1:1000
 | PTEN Antibody (T383/T382) (Cat# 102-13932) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the PTEN antibody detected the PTEN protein (arrow). |
Antigen Source
HUMAN
Storage/Stability
2-8°C (short-term); -20°C (long-term)
Expiration:
12 months from the date of shipment when stored properly.