Anti-Ptf1a (N-term) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Rabbit
Accession Number	Q7RTS3
Gene Id	256297
Gene Symbols	PTF1A
Protein Name / Synonyms	Ptf1a (N-term)
Clonality	Polyclonal
Preparation	This Ptf1a antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 12-43 amino acids from the N-terminal region of human Ptf1a.
Concentration (lot specific)	0.470 mg/ml
Recommended Applications	Western Blotting, IHC-P
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

Ptf1a is a component of the pancreas transcription factor 1 complex (PTF1) and is known to have a role in mammalian pancreatic development. The protein plays a role in determining whether cells allocated to the pancreatic buds continue towards pancreatic organogenesis or revert back to duodenal fates. This protein is thought to be involved in the maintenance of exocrine pancreas-specific gene expression including elastase 1 and amylase. Mutations in the Ptf1a gene cause cerebellar agenesis and loss of expression is seen in ductal type pancreas cancers.

Specificity

Predicted Reactivity

Rat

Other Names

PTF1A; BHLHA29; PTF1P48; Pancreas transcription factor 1 subunit alpha; Class A basic helix-loop-helix protein 29; Pancreas-specific transcription factor 1a; bHLH transcription factor p48; p48 DNA-binding subunit of transcription factor PTF1

NCBI Accession #

NP_835455.1

Other Accession #

Q64305

Format

Type

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

34970

Recommended Dilutions

WB: 1:1000; IHC: 1:10-50

	Western blot analysis of Ptf1a (arrow) using rabbit polyclonal Ptf1a Antibody (N-term) (Cat# 102-15069).293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the Ptf1a gene (Lane 2) (Origene Technologies).
	Formalin-fixed and paraffin-embedded human brain tissue reacted with Ptf1a Antibody (N-term) (Cat# 102-15069), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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