Anti-Rat CD106 Antibody

Product Description

Specifications

Size	0.1 mg
Estimated Lead Time	1-2 weeks
Species	Rat
Host Species	Mouse
Protein Name / Synonyms	CD106
Concentration (lot specific)	1.0mg/ml
Recommended Applications	Immunohistology - Frozen, Flow Cytometry, Immunofluorescence
Research Area	Cardiovascular Disease
Shipping Type	Blue ice
Storage	-20°C

Description

Specificity

This product specifically recognizes rat CD106, otherwise known as VCAM-1 (vascular adhesion molecule 1), a 110kDa inducible type I transmembrane glycoprotein and member of the immunoglobulin supergene family, which is predominantly expressed on vascular endothelium, and also on bone marrow stromal cells, follicular dendritic cells and some macrophages.

CD106 interacts with the lymphocyte homing receptor VLA-4 (alpha4 beta1 integrin) and LPAM-1 (alpha4 beta7 integrin) and mediates leucocyte-endothelial cell adhesion and signal transduction. Expression of CD106 is upregulated following cytokine activation, and endothelial CD106 plays a role in the extravasation of leucocytes from blood vessels during inflammation.

Storage/Stability

Store at +4 °C or at -20 °C if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 18 months after receipt.

Format

Supplied as:

Purified IgG - liquid

Formulation:

Phosphate buffered saline

Format Type:

Purified

Preparation

Immunogen:

Rat CD106-transfected L5178Y cells

Preservative:

0.09% Sodium Azide (NaN₃)

Expiration:

12 months from the date of shipment when stored properly.

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