Anti-Rat PRDM2 (RIZ1) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human, Mouse, Rat
Host Species	Rabbit
Accession Number	Q13029
Gene Id	7799
Gene Symbols	PRDM2
Protein Name / Synonyms	PRDM2 (RIZ1)
Clonality	Polyclonal
Preparation	Purified recombinant GST fusion protein encoding aa 245-573 of rat Riz1. This antibody also recognizes the isoform beta (Riz2) of PRDM2 (185 kDa).
Concentration (lot specific)	3.230 mg/ml
Recommended Applications	Western Blotting, IHC-P
Research Area	Cardiovascular Disease
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

PRDM2 is a 250-kD nuclear protein containing 8 zinc finger motifs. It contains an RB-binding motif that is related to that of the adenovirus E1A oncoprotein; RIZ also shares an antigenic epitope with the C terminus of E1A. It is expressed in human retinoblastoma cells and at low levels in all other human cell lines examined. Using fluorescence in situ hybridization, the PRDM2 gene has been mapped to 1p36. PRDM2 may be a candidate target of 1p36 alterations that commonly occur in neuroendocrine, breast, liver, colon, skin, and lymphoid tumors.

Specificity

Other Names

PRDM2; KMT8; RIZ; PR domain zinc finger protein 2; GATA-3-binding protein G3B; Lysine N-methyltransferase 8; MTB-ZF; MTE-binding protein; PR domain-containing protein 2; Retinoblastoma protein-interacting zinc finger protein; Zinc finger protein RIZ

NCBI Accession #

NP_001007258.1;NP_001129082.1;NP_036363.2;NP_056950.2

Other Accession #

NM_015866

Format

Type

Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

188915

Recommended Dilutions

IHC: 1:100-500

A) Rat B50 brain tumor cell extracts were immunoprecipitated with RIZ1 antibody (cat# 102-11360) or preimmune (ref.9). B)Immunohistochemical analysis of RIZ1 in adenovirus-transduced tumor cells. Established HCT116 xenograft tumors at day 2 after infection of AdRIZ1, Adnull, or buffer alone were processed for RIZ1 in situ detection (TUNEL) analysis (ref.10).

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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