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Anti-Rat R MKP3 Antibody
Catalog #: 102-17877
Rabbit Anti-Rat R MKP3 Antibody, 400 ul
Product Description
Specifications
| Size | 400 µL |
| Estimated Lead Time | 1-2 weeks |
| Species | Rat |
| Host Species | Rabbit |
| Accession Number | Q64346 |
| Gene Id | 116663 |
| Gene Symbols | DUSP6 |
| Protein Name / Synonyms | Rat R MKP3 |
| Clonality | Polyclonal |
| Preparation | This Rat MKP3 antibody is generated from rabbits immunized with a 6xHIS-tagged recombinant protein encoding aa 1~381 of rat MKP3. |
| Concentration (lot specific) | 2.0 mg/ml |
| Recommended Applications | Western Blotting, FC |
| Research Area | Cardiovascular Disease |
| Shipping Type | Blue ice |
| Storage | -20°C |
Description
Introduction
Dual specificity protein tyrosine phosphatases (dsPTPs) are a subfamily of protein tyrosine phosphatases implicated in the regulation of mitogen-activated protein kinase (MAPK). MKP-1 (also known as CL100, 3CH134, Erp, and hVH-1) exemplifies a class of dual-specificity phosphatase able to reverse the activation of MAP kinases by dephosphorylating critical tyrosine and threonine residues. MKP-3 is 36% identical to MKP-1 and it blocks both the phosphorylation and enzymatic activation of ERK2 by mitogens. MKP-3 mRNA is expressed in lung, heart, brain, and kidney, but not significantly in skeletal muscle or testis
Specificity
Other Names
Dusp6; Mkp3; Dual specificity protein phosphatase 6; Mitogen-activated protein kinase phosphatase 3
NCBI Accession #
NP_446335.1
Format
Type
Purified Rabbit Polyclonal Antibody (Pab)
Calculated Molecular Weight (Da)
42319
Recommended Dilutions
WB: 1:1000; FC: 1:10-50
 | Western blot analysis of MKP3 (arrow) using rabbit polyclonal MKP3-His6 Antibody (Cat# 102-17877). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the MKP3 gene. |
 | Rat MKP3 Antibody (Cat# 102-17877) flow cytometric analysis of 293 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. |
Antigen Source
RAT
Storage/Stability
2-8°C (short-term); -20°C (long-term)
Expiration:
12 months from the date of shipment when stored properly.