Anti-RET (Ascites) Antibody

Product Description

Specifications

Size	0.1 mL
Estimated Lead Time	1-2 weeks
Species	Human
Accession Number	P07949
Gene Id	5979
Gene Symbols	RET
Protein Name / Synonyms	RET (Ascites)
Clonality	Monoclonal
Preparation	This RET Monoclonal antibody was raised using purified His-tagged recombinant human RET.
Recommended Applications	Western Blotting, IHC-P, IF
Research Area	Cancer
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

This gene, a member of the cadherin superfamily, encodes one of the receptor tyrosine kinases, which are cell-surface molecules that transduce signals for cell growth and differentiation. This gene plays a crucial role in neural crest development, and it can undergo oncogenic activation in vivo and in vitro by cytogenetic rearrangement. Mutations in this gene are associated with the disorders multiple endocrine neoplasia, type IIA, multiple endocrine neoplasia, type IIB, Hirschsprung disease, and medullary thyroid carcinoma. Two transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their biological validity has not been confirmed.

Specificity

Other Names

RET; CDHF12; CDHR16; PTC; RET51; Proto-oncogene tyrosine-protein kinase receptor Ret; Cadherin family member 12; Proto-oncogene c-Ret; Soluble RET kinase fragment; Extracellular cell-membrane anchored RET cadherin 120 kDa fragment

NCBI Accession #

NP_065681.1;NP_066124.1

Other Accession #

NP_065681.1; NP_066124.1

Format

Type

Mouse Monoclonal Antibody (Mab)

Calculated Molecular Weight (Da)

124319

Recommended Dilutions

WB: 1:500-16000; IHC: 1:50-100; IF: 1:10-50

	RET (Cat# 102-10096) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the RET antibody detected the RET protein (arrow).
	RET Monoclonal( Ascites) (Cat# 102-10096) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the RET Monoclonal( Ascites) for immunohistochemistry. Clinical relevance has not been evaluated.
	Confocal immunofluorescent analysis of RET Antibody (Ascites)(Cat# 102-10096) with MDA-MB231 cell followed by Alexa Fluor 488-conjugated goat anti-mouse lgG (green).Actin filaments have been labeled with Alexa Fluor 555 phalloidin (red). DAPI was used to stain the cell nuclear (blue).

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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