Anti-RIC8A (Center) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Rabbit
Accession Number	Q9NPQ8
Gene Id	60626
Gene Symbols	RIC8A
Protein Name / Synonyms	RIC8A (Center)
Clonality	Polyclonal
Preparation	This RIC8A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 244-272 amino acids from the Central region of human RIC8A.
Concentration (lot specific)	0.5 mg/ml
Recommended Applications	Western Blotting
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex (By similarity). Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation.

Specificity

Predicted Reactivity

Monkey

Other Names

RIC8A; Synembryn-A; Protein Ric-8A

NCBI Accession #

NP_068751.4

Other Accession #

Q4R720; NP_068751.4

Format

Type

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

59710

Recommended Dilutions

WB: 1:1000

RIC8A Antibody (Center) (Cat# 102-13276) western blot analysis in A2058 cell line lysates (35ug/lane).This demonstrates the RIC8A antibody detected the RIC8A protein (arrow).

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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