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Anti-RNF19A (Center) Antibody
Catalog #: 102-12381
Rabbit Anti-Human RNF19A (Center) Antibody, 400 ul
Product Description
Specifications
| Size | 400 µL |
| Estimated Lead Time | 1-2 weeks |
| Species | Human |
| Host Species | Rabbit |
| Accession Number | Q9NV58 |
| Gene Id | 25897 |
| Gene Symbols | RNF19A |
| Protein Name / Synonyms | RNF19A (Center) |
| Clonality | Polyclonal |
| Preparation | This RNF19A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 384-413 amino acids from the Central region of human RNF19A. |
| Concentration (lot specific) | 0.5 mg/ml |
| Recommended Applications | Western Blotting, IHC-P |
| Shipping Type | Blue ice |
| Storage | -20°C |
Description
Introduction
The protein encoded this gene contains two RING-finger motifs and an IBR (in between RING fingers) motif. This protein is an E3 ubiquintin ligase that is localized in Lewy bodies (LBs), a characteristic neuronal inclusion in Parkinson's disease (PD) brains. This protein interacts with UBE2L3/UBCH7 and UBE2E2/UBCH8, but not other ubiquitin-conjugating enzymes. This protein is found to bind and ubiquitylate synphilin 1 (SNCAIP), which is a interacting protein of alpha synuclein in neurons, and a major component of LB. Alternatively spliced transcript variants encoding the same protein have been reported.
Specificity
Predicted Reactivity
Mouse, Pig
Other Names
RNF19A; RNF19; E3 ubiquitin-protein ligase RNF19A; Double ring-finger protein; RING finger protein 19A; p38
NCBI Accession #
NP_001267468.1;NP_056250.3;NP_904355.1
Other Accession #
Q2VJ60; P50636; NP_056250.3; NP_904355.1
Format
Type
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Calculated Molecular Weight (Da)
90696
Recommended Dilutions
WB: 1:1000; IHC: 1:10-50
 | RNF19A Antibody (Center) (Cat# 102-12381) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the RNF19A antibody detected the RNF19A protein (arrow). |
 | RNF19A Antibody (Center) (102-12381)immunohistochemistry analysis in formalin fixed and paraffin embedded human heart tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of RNF19A Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated. |
Antigen Source
HUMAN
Storage/Stability
2-8°C (short-term); -20°C (long-term)
Expiration:
12 months from the date of shipment when stored properly.