Anti-RON Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Rabbit
Accession Number	Q04912
Gene Id	4486
Gene Symbols	MST1R
Protein Name / Synonyms	RON
Clonality	Polyclonal
Preparation	This RON antibody is generated from rabbits immunized with two KLH conjugated synthetic peptides between 22-51 amino and 1370-1400 acids from the N-terminal and C-terminal regions of human RON.
Concentration (lot specific)	1.640 mg/ml
Recommended Applications	Western Blotting
Research Area	Cancer
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The tyrosine kinase (TK) group is mainly involved in the regulation of cell-cell interactions such as differentiation, adhesion, motility and death. There are currently about 90 TK genes sequenced, 58 are of receptor protein TK (e.g. EGFR, EPH, FGFR, PDGFR, TRK, and VEGFR families), and 32 of cytosolic TK (e.g. ABL, FAK, JAK, and SRC families).

Specificity

Other Names

MST1R; PTK8; RON; Macrophage-stimulating protein receptor; CDw136; Protein-tyrosine kinase 8; p185-Ron; CD_antigen=CD136; Macrophage-stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain

NCBI Accession #

NP_001231866.1;NP_002438.2

Format

Type

Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

152271

Recommended Dilutions

WB: 1:1000

Western blot analysis of anti-RON Pab (Cat# 102-17547) in THP1 cell lysate. RON (arrow) was detected using purified Pab. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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