Anti-RYK Antibody

Product Description

Specifications

Size	200 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Mouse
Accession Number	P34925
Gene Id	6259
Gene Symbols	RYK
Protein Name / Synonyms	Tyrosine-protein kinase RYK, 2.7.10.1, RYK, JTK5A
Clonality	Monoclonal
Clone	1671CT575.42.61
Isotype	Kappa, IgG1
Recommended Applications	FC, Western Blotting
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

May be a coreceptor along with FZD8 of Wnt proteins, such as WNT1, WNT3, WNT3A and WNT5A. Involved in neuron differentiation, axon guidance, corpus callosum establishment and neurite outgrowth. In response to WNT3 stimulation, receptor C- terminal cleavage occurs in its transmembrane region and allows the C-terminal intracellular product to translocate from the cytoplasm to the nucleus where it plays a crucial role in neuronal development.

Other Information

Antigen Type

Recombinant Protein

Format

Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.

Calculated Molecular Weight (Da)

67815

Antigen Source

Human

Images

FC (1:25)

Overlay histogram showing A431 cells stained with 102-20212(green line). The cells were fixed with 2% paraformaldehyde (10 min) and then permeabilized with 90% methanol for 10 min. The cells were then icubated in 2% bovine serum albumin to block non-specific protein-protein interactions followed by the antibody (102-20212, 1:25 dilution) for 60 min at 37ºC. The secondary antibody used was Goat-Anti-Mouse IgG, DyLight® 488 Conjugated Highly Cross-Adsorbed(OJ192088) at 1/200 dilution for 40 min at 37ºC. Isotype control antibody (blue line) was mouse IgG1 (1?g/1x10

Expiration:

12 months from the date of shipment when stored properly.

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