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Anti-SGOL1 (Center) Antibody
Catalog #: 102-22633
Rabbit Anti-SGOL1 (Center) Antibody, 400 µl
Product Description
Specifications
| Size | 400 µL |
| Estimated Lead Time | 1-2 weeks |
| Species | Human |
| Host Species | Rabbit |
| Accession Number | Q5FBB7|NP_001012409.1|NP_001012410.1 |
| Gene Id | 151648 |
| Gene Symbols | SGO1 |
| Protein Name / Synonyms | Shugoshin-like 1, hSgo1, Serologically defined breast cancer antigen NY-BR-85, SGOL1, SGO1 |
| Clonality | Polyclonal |
| Clone | RB36785 |
| Isotype | Kappa, Rabbit |
| Recommended Applications | Western Blotting |
| Shipping Type | Blue ice |
| Storage | -20°C |
Description
Introduction
SGOL1 plays a central role in chromosome cohesion during mitosis by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms. May act by preventing phosphorylation of the STAG2 subunit of cohesin complex at the centromere, ensuring cohesin persistence at centromere until cohesin cleavage by ESPL1/separase at anaphase. Essential for proper chromosome segregation during mitosis and this function requires interaction with PPP2R1A. Its phosphorylated form is necessary for chromosome congression and for the proper attachment of spindle microtubule to the kinetochore. Necessary for kinetochore localization of PLK1 and CENPF. May play a role in the tension sensing mechanism of the spindle-assembly checkpoint by regulating PLK1 kinetochore affinity. Isoform 3 plays a role in maintaining centriole cohesion involved in controlling spindle pole integrity.
Other Information
NCBI Accession #
NP_001012409.1;NP_001012410.1;NP_001012411.1;NP_001012412.1;NP_001012413.1;NP_001186180.1;NP_001186181.1;NP_001186182.1;NP_001186183.1;NP_001186184.1;NP_001186185.1;NP_001186186.1;NP_612493.1
Antigen Type
Synthetic Peptide
Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Calculated Molecular Weight (Da)
64190
Antigen Source
Human
Images
WB (1:1000)
SGOL1 Antibody (Center) (Cat. #102-22633) western blot analysis in MCF-7 cell line lysates (35ug/lane).This demonstrates the SGOL1 antibody detected the SGOL1 protein (arrow).
Storage/Stability
2-8°C (short-term); -20°C (long-term)
Expiration:
12 months from the date of shipment when stored properly.