Anti-SGOL2 (Center) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Rabbit
Accession Number	Q562F6
Gene Id	151246
Gene Symbols	SGOL2
Protein Name / Synonyms	SGOL2 (Center)
Clonality	Polyclonal
Preparation	This SGOL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 391-419 amino acids from the Central region of human SGOL2.
Concentration (lot specific)	0.5 mg/ml
Recommended Applications	Western Blotting
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

Cooperates with PPP2CA to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I. Has a crucial role in protecting REC8 at centromeres from cleavage by separase. During meiosis, protects centromeric cohesion complexes until metaphase II/anaphase II transition, preventing premature release of meiosis-specific REC8 cohesin complexes from anaphase I centromeres. Is thus essential for an accurate gametogenesis. May act by targeting PPP2CA to centromeres, thus leading to cohesin dephosphorylation (By similarity). Essential for recruiting KIF2C to the inner centromere and for correcting defective kinetochore attachments.

Specificity

Other Names

SGOL2; Shugoshin-like 2; Shugoshin-2; Tripin

NCBI Accession #

NP_001153518.1;NP_689737.4

Other Accession #

NP_689737.3

Format

Type

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

144739

Recommended Dilutions

WB: 1:1000

SGOL2 Antibody (Center) (Cat# 102-14552) western blot analysis in U-937 cell line lysates (35ug/lane).This demonstrates the SGOL2 antibody detected the SGOL2 protein (arrow).

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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