Anti-SMAD1 (N-term) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Rabbit
Accession Number	Q15797
Gene Id	4086
Gene Symbols	SMAD1
Protein Name / Synonyms	SMAD1 (N-term)
Clonality	Polyclonal
Preparation	This SMAD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human SMAD1.
Concentration (lot specific)	0.400 mg/ml
Recommended Applications	Western Blotting
Research Area	Angiogenesis, Inflammation, TGF-beta Signaling
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed.

Specificity

Predicted Reactivity

Mouse, Rat, Zebrafish, Bovine, Chicken

Other Names

SMAD1; BSP1; MADH1; MADR1; Mothers against decapentaplegic homolog 1; JV4-1; Mad-related protein 1; SMAD family member 1; Transforming growth factor-beta-signaling protein 1

NCBI Accession #

NP_001003688.1;NP_005891.1

Other Accession #

O54835; Q9JIW5; O15198; Q9R1V3; P97454; Q99717; Q9W7E7; Q56I99; P97588; P70340; Q9I8V2; Q1JQA2; NP_005891.1

Format

Type

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

52260

Recommended Dilutions

WB: 1:1000

SMAD1 Antibody (N-term) (Cat# 102-14565) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the SMAD1 antibody detected the SMAD1 protein (arrow).

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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