Rabbit Anti-Smad2 (Ab-465) Antibody, 100 µg
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Product Description
Specifications
| Size | 100 µL |
| Estimated Lead Time | 1-2 weeks |
| Species | Human, Mouse, Rat |
| Host Species | Rabbit |
| Accession Number | Q15796 |
| Gene Id | 4087 |
| Gene Symbols | SMAD2 |
| Protein Name / Synonyms | Smad2 (Ab-465) |
| Clonality | Polyclonal |
| Recommended Applications | Western Blotting |
| Research Area | Cardiovascular Disease, TGF-beta Signaling |
| Shipping Type | Blue ice |
| Storage | -20°C |
Introduction
Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.
Specificity
Other Names
Mothers against decapentaplegic homolog 2, MAD homolog 2, Mothers against DPP homolog 2, JV18-1, Mad-related protein 2, hMAD-2, SMAD family member 2, SMAD 2, Smad2, hSMAD2, SMAD2, MADH2, MADR2
Format
Type
Purified Rabbit Polyclonal Antibody (Pab)
Calculated Molecular Weight (Da)
52306
Recommended Dilutions
WB: 1:1000
 | Western blot analysis of lysates from HepG2,NIH/3T3 cell line (from left to right),using Smad2 Antibody (Ab-465)(B9058). B9058 was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody.Lysates at 35ug per lane. |
Storage/Stability
2-8°C (short-term); -20°C (long-term)
Expiration:
12 months from the date of shipment when stored properly.