3607 Parkway Ln Ste 200 Norcross, Georgia 30092
www.RayBiotech.com | info@raybiotech.com
770-729-2992 | +1-888-494-8555
ISO 13485:2016 cGMP
Anti-SMC1A (N-terminus) Antibody
Catalog #: 102-26430
Mouse Anti-SMC1A (N-terminus) Antibody, 100 µl
Product Description
Specifications
| Size | 100 µL |
| Estimated Lead Time | 1-2 weeks |
| Species | Human |
| Host Species | Mouse |
| Accession Number | Q14683 |
| Gene Id | 8243 |
| Gene Symbols | SMC1A |
| Protein Name / Synonyms | Chromosome segregation protein SmcB;DXS423E;KIAA0178;MGC138332;Sb1.8;Segregation of mitotic chromosomes 1;SMC protein 1A;SMC-1-alpha;SMC-1A;SMC1 (structural maintenance of chromosomes 1 yeast) like 1;SMC1;SMC1 structural maintenance of chromosomes 1 like 1;SMC1A;SMC1A_HUMAN;SMC1alpha;SMC1L1;SMCB;Structural maintenance of chromosomes 1A;Structural maintenance of chromosomes protein 1A. |
| Clonality | Monoclonal |
| Recommended Applications | Western Blotting, IHC, FC |
| Shipping Type | Blue ice |
| Storage | -20°C |
Description
Introduction
Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, or via its phosphorylation by ATR. Works as a downstream effector both in the ATM/NBS1 branch and in the ATR/MSH2 branch of S-phase checkpoint.
Other Information
Antigen Type
Recombinant Protein
Images
WB (1:1000)
Western blot detection of SMC1A(N-terminus) in HelaNE,Jurkat and A431 cell lysates using SMC1A (N-terminus) mouse mAb (1:1000 diluted).Predicted band size: 143KDa.Observed band size: 143KDa.
IHC (1:500)
IHC of paraffin-embedded human colon using anti-SMC1A (N-terminus) mouse mAb diluted 1/500-1/1000.
FC (1:100)
Flow Cytometry analysis of HeLa cells stained with SMC1A (N-terminus) (red, 1/100 dilution), followed by FITC-conjugated goat anti-mouse IgG. Black line histogram represents the isotype control, normal mouse IgG.
Storage/Stability
2-8°C (short-term); -20°C (long-term)
Expiration:
12 months from the date of shipment when stored properly.