Anti-SOS1 Antibody

Catalog #: DS-MB-03549

Mouse Anti-Human SOS1

Product Description

Specifications

Size	0.1 mg
Estimated Lead Time	1-2 weeks
Species	Human
Specificity	This product specifically recognizes SOS1 (son of sevenless homolog 1), a ubiquitously expressed 150kDa intracellular protein and bifunctional guanine nucleotide exchange factor (GEF), which plays a role in growth and differentiation signalling pathways and in actin reorganization, by acting as a regulator of Ras and Rac/Rho GTPases. Mutations in the SOS1 gene are responsible for the rare oral overgrowth condition known as gingival fibromatosis 1 (GINGF1), and also the cause of the relatively common autosomal dominant disorder Noonan syndrome type 4 (NS4), characterized by short stature, congenital heart malformation, bleeding diathesis and distinctive facial features.
Host Species	Mouse
Protein Name / Synonyms	SOS1
Concentration (lot specific)	IgG concentration 1.0mg/ml
Recommended Applications	ELISA (dilution: , 1.0ug/ml), Immunofluorescence, Western Blotting
Shipping Type	Blue ice
Storage	-20°C

Description

This product detects a band of approximately 150kDa in K562 and RAJI human cell lysates under reducing conditions.

Storage/Stability

Store at +4 °C or at -20 °C if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 18 months after receipt.

Format

Supplied as:

Purified IgG - liquid

Formulation:

Phosphate buffered saline

Format Type:

Purified

Preparation

Immunogen:

Synthetic peptide corresponding to amino acids THPSMHRDGPPLLENAHSS of human SOS1.

Preservative:

0.09% Sodium Azide (NaN₃)

Expiration:

12 months from the date of shipment when stored properly.

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