Anti-SRC8 (N-term) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Rabbit
Accession Number	Q14247
Gene Id	2017
Gene Symbols	CTTN
Protein Name / Synonyms	SRC8 (N-term)
Clonality	Polyclonal
Preparation	This SRC8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 9-38 amino acids from the N-terminal region of human SRC8.
Concentration (lot specific)	0.5 mg/ml
Recommended Applications	Western Blotting, IHC-P
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

SRC8 is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This protein has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this protein contributes to tumor cell invasion and metastasis.

Specificity

Predicted Reactivity

Mouse, Chicken

Other Names

CTTN; EMS1; Src substrate cortactin; Amplaxin; Oncogene EMS1

NCBI Accession #

NP_001171669.1;NP_005222.2;NP_612632.1

Other Accession #

Q60598; Q01406

Format

Type

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

61586

Recommended Dilutions

WB: 1:1000; IHC: 1:50-100

	Western blot analysis of SRC8 Antibody (N-term) (Cat# 102-18203) in HL-60 cell line lysates (35ug/lane). SRC8 (arrow) was detected using the purified Pab.
	Formalin-fixed and paraffin-embedded human breast carcinoma with SRC8 Antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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