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Anti-STAT1 Antibody
Catalog #: 102-10456
Mouse Anti-Human STAT1 Antibody, 400 ul
Product Description
Specifications
| Size | 400 µL |
| Estimated Lead Time | 1-2 weeks |
| Species | Human |
| Accession Number | P42224 |
| Gene Id | 6772 |
| Gene Symbols | STAT1 |
| Protein Name / Synonyms | STAT1 |
| Clonality | Monoclonal |
| Preparation | Purified His-tagged STAT1 protein was used to produced this monoclonal antibody. |
| Concentration (lot specific) | 0.500 mg/ml |
| Recommended Applications | Western Blotting |
| Research Area | Angiogenesis, Cancer |
| Shipping Type | Blue ice |
| Storage | -20°C |
Description
Introduction
Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and growth factors. Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine-and serine-phosphorylated. It then forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state. Becomes activated in response to KITLG/SCF and KIT signaling. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4.
Specificity
Other Names
STAT1;Signal transducer and activator of transcription 1-alpha/beta; Signal transducer and activator of transcription 1-alpha/beta; Transcription factor ISGF-3 components p91/p84
NCBI Accession #
NP_009330.1;NP_644671.1
Format
Type
Mouse Monoclonal Antibody (Mab)
Calculated Molecular Weight (Da)
87335
Recommended Dilutions
WB: 1:1000
 | STAT1 Antibody(Cat# 102-10456) western blot analysis in CEM,Hela cell line lysates (35ug/lane).This demonstrates the STAT1 antibody detected the STAT1 protein (arrow). |
Antigen Source
Human
Storage/Stability
2-8°C (short-term); -20°C (long-term)
Expiration:
12 months from the date of shipment when stored properly.