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Anti-Stat2 (p690) (Phospho) Antibody, Biotinylated
Catalog #: RB-02-0017B-50
Rabbit anti-Stat2 (p690) (Phosph) Biotinylated Antibody, 50 ug
Product Description
Specifications
| Size | 50 µg |
| Estimated Lead Time | 1-2 business days |
| Species | Human |
| Host Species | Rabbit |
| Accession Number | P52630 |
| Gene Id | 6773 |
| Gene Symbols | STAT2 |
| Clonality | Polyclonal |
| Immunogen | The imunogen was synthetic peptide. This antibody was produced from a rabbit immunized with the immunogen. The IgG fraction was purified from rabbit serum followed by Protein A/G affinity chromatography. |
| Immunogen Sequence | CRRKY(P)LKHRLI |
| Isotype | IgG |
| Recommended Applications | ELISA (recommended work dilution= 1:2, 000) |
| Reconstitution | A separate vial of dilution buffer is provided for reconstitution. The antibody is supplied lyophilized, originally containing PBS, without preservative stabilizers (e.g. sodium azide). The final amount is indicated on the shipping vial. |
| Shipping Type | Ambient temperature |
| Storage | -20°C |
Description
Description
Stat2 is one of seven members of the Signal transducer and activators of transcription (Stats) family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor-associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. Stat2 is a latent transcription factor that functions both as a signal transducer in the cytoplasm and an activator of transcription in the nucleusStat2 is phosphorylated at Tyr690 by JAKs. Additionally, upon activation, Stat2 will form a multi-protein DNA-binding complex with Stat-1 and ISGF3?p48. This activation subsequently allows the complex to translocate to the nucleus & bind specific enhancer elements.
Storage / Stability
The antibody is stable for at least 1 year from the date of receipt when stored at -20°C to -70°C. Reconstituted antibody can also be aliquotted and stored at 4°C for 1 month or at -20°C to -70°C in a manual defrost freezer for many months without detectable loss activity. Please avoid freeze-thaw cycles.
Specificity
This antibody binds to its immunogen, and did not show any cross reactivity with unrelated antigens in ELISA. Cross reactivity with mouse and rat Stat2 has not yet been tested.
Related Products
- Rabbit Anti-STAT1 alpha, C-terminus (catalog #: 129-10618)
- Rabbit Anti-Human STAT3 (p705) (catalog #: RB-02-0018)
References
- Romero-Weaver AL, et al.. (2010) Resistance to IFN-alpha-induced apoptosis is linked to a loss of STAT2. Mol Cancer Res.8(1):80-92.
- Melen K, et al..(2001) Arginine/lysine-rich structural element is involved in interferon-induced nuclear import of STATs. J Biol Chem. 276(19):16447-55.
Expiration:
12 months from the date of shipment when stored properly.