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Anti-Stat2 (p690) (Phospho) Antibody
Catalog #: RB-02-0017
Rabbit anti-Human Stat2 (p690) (Phosph) Antibody
Product Description
Specifications
| Size | 20 µg, 100 µg, 200 µg, 500 µg |
| Estimated Lead Time | 1-2 business days |
| Species | Human |
| Specificity | This antibody binds to its immunogen, and did not show any cross reactivity with unrelated antigens in ELISA. Cross reactivity with mouse and rat Stat2 has not yet been tested. |
| Accession Number | P52630 |
| Gene Id | 6773 |
| Gene Symbols | STAT2 |
| Clonality | Polyclonal |
| Immunogen | The imunogen was synthetic peptide. This antibody was produced from a rabbit immunized with the immunogen. The IgG fraction was purified from rabbit serum followed by Protein A/G affinity chromatography. |
| Immunogen Sequence | CRRKY(P)LKHRLI |
| Recommended Applications | ELISA (recommended work dilution= 1:2, 000) |
| Reconstitution | Product is supplied as a powder obtained from lyophilization of purified antibody in PBS without preservatives. Reconstitute the antibody with sterile water to a final concentration of 1 mg/ml. |
| Shipping Type | Ambient temperature |
| Storage | -20°C |
Description
Description
Stat2 is one of seven members of the Signal transducer and activators of transcription (Stats) family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor-associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. Stat2 is a latent transcription factor that functions both as a signal transducer in the cytoplasm and an activator of transcription in the nucleusStat2 is phosphorylated at Tyr690 by JAKs. Additionally, upon activation, Stat2 will form a multi-protein DNA-binding complex with Stat-1 and ISGF3?p48. This activation subsequently allows the complex to translocate to the nucleus & bind specific enhancer elements.
Typical Data
Storage/Stability
Store at 4°C if intended for use within one month, otherwise, store at -20°C to -80°C. The lyophilized antibody is stable for at least 18 months after the date of receipt when stored at -20°C to -80°C. After reconstitution, it can be aliquoted and stored frozen at -20°C to -80°C in a manual defrost freezer for at least 6 months without detectable loss of activity. Upon reconstitution, the antibody can also be stored for 1 month at 4°C. Please avoid multiple freeze-thaw cycles, as this will lower the activity of the antibody.
Expiration
12 months from the date of shipment when stored properly.
References
- Romero-Weaver AL, et al.. (2010) Resistance to IFN-alpha-induced apoptosis is linked to a loss of STAT2. Mol Cancer Res.8(1):80-92.
- Melen K, et al..(2001) Arginine/lysine-rich structural element is involved in interferon-induced nuclear import of STATs. J Biol Chem. 276(19):16447-55.