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Anti-Substance P Antibody
Catalog #: 130-10002
Rabbit Anti-Human Substance P Antibody
Product Description
Specifications
| Size | 20 µg, 100 µg, 200 µg, 500 µg |
| Estimated Lead Time | 1-2 business days |
| Species | Human |
| Accession Number | NM_003182 |
| Clonality | Polyclonal |
| Immunogen | Immunogen was synthetic peptide derived from human Subtance P. This antibody was produced from a rabbit immunized with the immunogen. The IgG fraction of serum supernatant was purified followed by Protein A/G affinity chromatography. |
| Immunogen Sequence | CRPKPQQFFGLM |
| Recommended Applications | ELISA (recommended work dilution= 1: 4, 000(at least detecting 250ng/ml)) |
| Reconstitution | Supplied as lyophilized and purified antibody originally containing PBS, without Preservative Stabilizers, such as Sodium Azide. The final concentration is indicated on the shipping vial. The antibody is stable for at least years from the data of receipt when stored at -20°C to -70°C. Reconstituted antibody (recommended with H20 1 mg/ml) can also be aliquoted and stored frozen at -20°C to -70°C in a manual defrost freezer for months without detectable loss activity. Upon reconstitution, the antibody can also be stored over months at 4°C. Please avoid freeze-thaw cycles. |
| Research Area | Neuroscience |
| Shipping Type | Ambient temperature |
| Storage | -20°C |
Description
Description
In the field of neuroscience, Substance P (SP) is a neuropeptide: an undecapeptide that functions as a neurotransmitter and as a neuromodulator. It belongs to the tachykinin neuropeptide family. Substance P is released from the terminals of specific sensory nerves, it is found in the brain and spinal cord, and is associated with inflammatory processes and pain. Substance P receptor antagonists may have important therapeutic applications in the treatment of a variety of stress-related illnesses, in addition to their potential as analgesics. The deduced amino acid sequence of Substance P is as follows:Arg-Pro-LysPro-Gln-Gln-Phe-Phe-Gly-Leu-Met.
Specificity
The antibody can specifically bind to its immunogen, and did not show any cross reactivity with unrelated antigens in ELISA. The specificity for binding to recombinant protein, cellular protein and native antigen is not defined. Cross reactivity with mouse and rat Subtance P has not yet been tested.
Storage
Store at -20°C, if not intended for use within a month, keep it at 4°C and minimize freezing and thawing when use.
Related Products
Rabbit Anti-Human Substance P (CAT# DS-PB-01889)Mouse Anti-Substance P (CAT# MD-14-0532); Rat Anti-Substance P (CAT# DS-MB-02346)
References
- P. Datar, et al., (2004) Substance P: structure, function, and therapeutics. Current topics in medicinal chemistry 4 (1): 75103.
Expiration:
12 months from the date of shipment when stored properly.