Anti-SYVN1 (HRD1) (N-term) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Rabbit
Accession Number	Q86TM6
Gene Id	84447
Gene Symbols	SYVN1
Protein Name / Synonyms	SYVN1 (HRD1) (N-term)
Clonality	Polyclonal
Preparation	This SYVN1 (HRD1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 58-88 amino acids from the N-terminal region of human SYVN1 (HRD1).
Concentration (lot specific)	2.0 mg/ml
Recommended Applications	Western Blotting
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

HRD1 is a ubiquitin ligase whose expression is induced by the unfolded protein response (UPR) following endoplasmic reticulum stress. Expression of HRD1 protects cells from apoptosis by inducing degradation of abnormally processed proteins that accumulate in the endoplasmic reticulum. HRD1 is expressed in many tissues, strongly expressed in brain, pancreas, liver, kidney and skeletal muscle. Synoviolin/Hrd1 (expressed in rheumatoid synovium) is reported to be a novel causative factor for arthropathy by triggering synovial cell outgrowth through its antiapoptotic effects. HRD1 contains one ring-type zinc finger.

Specificity

Predicted Reactivity

Mouse, Xenopus

Other Names

SYVN1; HRD1; KIAA1810; E3 ubiquitin-protein ligase synoviolin; Synovial apoptosis inhibitor 1

NCBI Accession #

NP_115807.1;NP_757385.1

Other Accession #

Q5XHH7; Q6NRL6; Q9DBY1; Q8N6E8

Format

Type

Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

67685

Recommended Dilutions

WB: 1:1000

Western blot analysis of anti-HRD1 Pab (Cat# 102-15012) in mouse brain tissue lysate (35ug/lane). HRD1(arrow) was detected using the purified Pab.

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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