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Anti-TGF Beta Receptor I (Center) Antibody
Catalog #: 102-17643
Rabbit Anti-TGF Beta Receptor I (Center) Antibody, 400 ul
Product Description
Specifications
| Size | 400 µL |
| Estimated Lead Time | 1-2 weeks |
| Species | Human, Mouse |
| Host Species | Rabbit |
| Accession Number | P36897 |
| Gene Id | 7046 |
| Gene Symbols | TGFBR1 |
| Protein Name / Synonyms | TGF Beta Receptor I (Center) |
| Clonality | Polyclonal |
| Preparation | This TGF Beta Receptor I antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 134-163 amino acids from the Central region of human TGF Beta Receptor I. |
| Concentration (lot specific) | 2.000 mg/ml |
| Recommended Applications | Western Blotting |
| Research Area | Angiogenesis, Cardiovascular Disease, Cancer |
| Shipping Type | Blue ice |
| Storage | -20°C |
Description
Introduction
The protein encoded by this gene forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine protein kinase. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS).
Specificity
Predicted Reactivity
Rat, Bovine, Pig
Other Names
TGFBR1; ALK5; SKR4; TGF-beta receptor type-1; Activin A receptor type II-like protein kinase of 53kD; Activin receptor-like kinase 5; Serine/threonine-protein kinase receptor R4; TGF-beta type I receptor; Transforming growth factor-beta receptor type I
NCBI Accession #
NP_001124388.1;NP_004603.1
Other Accession #
P80204; Q5CD18; Q64729; O46680
Format
Type
Purified Rabbit Polyclonal Antibody (Pab)
Calculated Molecular Weight (Da)
55960
Recommended Dilutions
WB: 1:1000; IHC: 1:50-100
 | Western blot analysis of anti-TGFBR1 Pab (Cat# 102-17643) in Jurkat cell line lysates (35ug/lane). TGFBR1 (arrow) was detected using the purified Pab. |
 | Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma. |
Antigen Source
HUMAN
Storage/Stability
2-8°C (short-term); -20°C (long-term)
Expiration:
12 months from the date of shipment when stored properly.