Anti-TGFB1 (N-term) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human, Mouse
Host Species	Rabbit
Accession Number	P01137
Gene Id	7040
Gene Symbols	TGFB1
Protein Name / Synonyms	TGFB1 (N-term)
Clonality	Polyclonal
Preparation	This TGFB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 22-50 amino acids from the N-terminal region of human TGFB1.
Concentration (lot specific)	0.5 mg/ml
Recommended Applications	Western Blotting, IHC-P, IF
Research Area	Angiogenesis, Cancer, Inflammation, TGF-beta Signaling
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

TGFB1 is a member of the transforming growth factor beta (TGFB) family of cytokines, which are multifunctional peptides that regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types. Many cells have TGFB receptors, and the protein positively and negatively regulates many other growth factors. The secreted protein is cleaved into a latency-associated peptide (LAP) and a mature TGFB1 peptide, and is found in either a latent form composed of a TGFB1 homodimer, a LAP homodimer, and a latent TGFB1-binding protein, or in an active form composed of a TGFB1 homodimer. The mature peptide may also form heterodimers with other TGFB family members. This gene is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease.

Specificity

Predicted Reactivity

Rat, Bovine, Pig

Other Names

TGFB1; TGFB; Transforming growth factor beta-1; Latency-associated peptide

NCBI Accession #

NP_000651.3

Other Accession #

P17246; P07200; P04202; P18341; NP_000651.3

Format

Type

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

44341

Recommended Dilutions

WB: 1:1000; IHC: 1:10-50; IF: 1:10-50

	TGFB1 Antibody (N-term) (Cat# 102-11520) western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the TGFB1 antibody detected the TGFB1 protein (arrow).
	TGFB1 Antibody (N-term) (Cat# 102-11520)immunohistochemistry analysis in formalin fixed and paraffin embedded human breast carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of TGFB1 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
	Confocal immunofluorescent analysis of TGFB1 Antibody (N-term) (Cat# 102-11520) with HepG2 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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