Anti-TGFBR2 (N-term) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human, Mouse
Host Species	Rabbit
Accession Number	P37173
Gene Id	7048
Gene Symbols	TGFBR2
Protein Name / Synonyms	TGFBR2 (N-term)
Clonality	Polyclonal
Preparation	This TGFBR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 13-40 amino acids from the N-terminal region of human TGFBR2.
Concentration (lot specific)	0.500 mg/ml
Recommended Applications	Western Blotting, IHC-P, IF
Research Area	Angiogenesis, Cardiovascular Disease, Cancer, TGF-beta Signaling
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

This gene encodes a member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. The encoded protein is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with another receptor protein, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized.

Specificity

Other Names

TGFBR2; TGF-beta receptor type-2; TGF-beta type II receptor; Transforming growth factor-beta receptor type II

NCBI Accession #

NP_001020018.1;NP_003233.4

Other Accession #

NP_003233.4; NP_001020018.1

Format

Type

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

64568

Recommended Dilutions

WB: 1:1000; IHC: 1:10-50; IF: 1:10-50

	TGFBR2 Antibody (N-term) (Cat# 102-11283) western blot analysis in mouse lung tissue lysates (35ug/lane).This demonstrates the TGFBR2 antibody detected the TGFBR2 protein (arrow).
	TGFBR2 Antibody (N-term) (Cat# 102-11283)immunohistochemistry analysis in formalin fixed and paraffin embedded human placenta tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of TGFBR2 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
	Confocal immunofluorescent analysis of TGFBR2 Antibody (N-term) (Cat# 102-11283) with HepG2 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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