Anti-TGIF1 (Center L223) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human, Mouse
Host Species	Rabbit
Accession Number	Q15583
Gene Id	7050
Gene Symbols	TGIF1
Protein Name / Synonyms	TGIF1 (Center L223)
Clonality	Polyclonal
Preparation	This TGIF1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 208-237 amino acids from the Central region of human TGIF1.
Concentration (lot specific)	2.000 mg/ml
Recommended Applications	Western Blotting
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

The protein encoded by this gene is a member of the three-amino acid loop extension (TALE) superclass of atypical homeodomains. TALE homeobox proteins are highly conserved transcription regulators. This particular homeodomain binds to a previously characterized retinoid X receptor responsive element from the cellular retinol-binding protein II promoter. In addition to its role in inhibiting 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element, the protein is an active transcriptional co-repressor of SMAD2 and may participate in the transmission of nuclear signals during development and in the adult. Mutations in this gene are associated with holoprosencephaly type 4, which is a structural anomaly of the brain. Alternative splicing has been observed at this locus and eight variants, encoding four distinct isoforms, are described.

Specificity

Predicted Reactivity

Chicken

Other Names

TGIF1; TGIF; Homeobox protein TGIF1; 5'-TG-3'-interacting factor 1

NCBI Accession #

NP_001265611.1;NP_001265613.1;NP_001265615.1;NP_003235.1;NP_733796.2;NP_775299.1;NP_775300.1;NP_775301.1;NP_775302.1;NP_775303.1;NP_777480.1

Other Accession #

Q8C0Y1; Q9GZN2; P70284; Q90655; NP_003235.1; NP_733796.2

Format

Type

Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

43013

Recommended Dilutions

WB: 1:1000

	Western blot analysis of TGIF1 (arrow) using rabbit polyclonal TGIF1 Antibody (Center L223) (Cat# 102-11377). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the TGIF1 gene.
	TGIF1 Antibody (Center L223) (Cat# 102-11377) western blot analysis in mouse bladder tissue lysates (35ug/lane).This demonstrates the TGIF1 antibody detected the TGIF1 protein (arrow).

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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