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Anti-THOC6 (Center) Antibody
Catalog #: 102-13928
Rabbit Anti-THOC6 (Center) Antibody, 400 ul
Product Description
Specifications
| Size | 400 µL |
| Estimated Lead Time | 1-2 weeks |
| Species | Human, Mouse |
| Host Species | Rabbit |
| Accession Number | Q86W42 |
| Gene Id | 79228 |
| Gene Symbols | THOC6 |
| Protein Name / Synonyms | THOC6 (Center) |
| Clonality | Polyclonal |
| Preparation | This THOC6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 96-123 amino acids from the Central region of human THOC6. |
| Concentration (lot specific) | 0.5 mg/ml |
| Recommended Applications | Western Blotting |
| Shipping Type | Blue ice |
| Storage | -20°C |
Description
Introduction
Component of the THO subcomplex of the TREX complex. The TREX complex specifically associates with spliced mRNA and not with unspliced pre-mRNA. It is recruited to spliced mRNAs by a transcription-independent mechanism. Binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing-and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export. The recruitment occurs via an interaction between THOC4 and the cap-binding protein NCBP1. UAP56 functions as a bridge between THOC4 and the THO complex. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. The recruitment of the TREX complex to the intronless viral mRNA occurs via an interaction between KSHV ORF57 protein and THOC4.
Specificity
Predicted Reactivity
Rat
Other Names
THOC6; WDR58; THO complex subunit 6 homolog; Functional spliceosome-associated protein 35; WD repeat-containing protein 58
NCBI Accession #
NP_001135822.1;NP_077315.2
Other Accession #
Q6AY87; Q5U4D9; NP_001135822.1
Format
Type
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Calculated Molecular Weight (Da)
37535
Recommended Dilutions
WB: 1:1000
 | THOC6 Antibody (Center) (Cat# 102-13928) western blot analysis in mouse Neuro-2a cell line lysates (35ug/lane).This demonstrates the THOC6 antibody detected the THOC6 protein (arrow). |
Antigen Source
HUMAN
Storage/Stability
2-8°C (short-term); -20°C (long-term)
Expiration:
12 months from the date of shipment when stored properly.