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Anti-Thrombospondin-1 (TSP1) Antibody, Biotinylated
Catalog #: 130-00002B-50
Rabbit anti-Thrombospondin-1 (TSP1) Biotinylated Antibody, 50 ug
Product Description
Specifications
| Size | 50 µg |
| Estimated Lead Time | 1-2 business days |
| Species | Human |
| Host Species | Rabbit |
| Accession Number | P07996 |
| Gene Id | 7057 |
| Gene Symbols | THBS1 TSP TSP1 |
| Clonality | Polyclonal |
| Immunogen | The immunogen was a synthetic peptide. This antibody was produced from a rabbit immunized with this peptide conjugated with KLH. The IgG fraction was purified from rabbit serum by Protein G affinity chromatography. |
| Isotype | IgG |
| Recommended Applications | ELISA (recommended work dilution= 1: 64, 000) |
| Reconstitution | A separate vial of dilution buffer is provided for reconstitution. The antibody is supplied lyophilized, originally containing PBS, without preservative stabilizers (e.g. sodium azide). The final amount is indicated on the shipping vial. |
| Research Area | Angiogenesis, Cancer, Inflammation |
| Shipping Type | Ambient temperature |
| Storage | -20°C |
Description
Description
Thrombospondin 1 (TSP-1) is a glycoprotein that is released from platelet alpha-granules in response to thrombin stimulation and is also a transient component of the extracellular matrix in developing and repairing tissues. TSP-1 is a subunit of a disulfide-linked homotrimeric protein. TSP-1 is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. TSP-1 can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta-1. This protein has been shown to play roles in platelet aggregation, angiogenesis, and tumorigenesis. Medical interest in thrombospondin-1 focuses on its roles in haemostasis and its effects on angiogenesis.
Storage / Stability
The antibody is stable for at least 1 year from the date of receipt when stored at -20°C to -70°C. Reconstituted antibody can also be aliquotted and stored at 4°C for 1 month or at -20°C to -70°C in a manual defrost freezer for many months without detectable loss activity. Please avoid freeze-thaw cycles.
Specificity
This antibody recognizes human TSP-1. Cross reactivity with mouse and rat TSP-1 was detected.
References
- Wolf, FW. et al. (1990). "Structure and chromosomal localization of the human thrombospondin gene". Genomics 6 (4): 68591.
- Jaffe, E. et al. (1990). "Mapping of the thrombospondin gene to human chromosome 15 and mouse chromosome 2 by in situ hybridization". Genomics 7 (1): 1236.
Expiration:
12 months from the date of shipment when stored properly.