RayBiotech

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Anti-Thyroid Stimulating Hormone Receptor / TSHR Antibody (beta chain)

Catalog #: 188-11201

Mouse anti-Human Thyroid Stimulating Hormone Receptor / TSHR Antibody (beta chain)

Product Description

Specifications

Size20 µg, 100 µg
Estimated Lead Time1-2 weeks
SpeciesHuman
Host SpeciesMouse
Accession Number
P16473
Gene Id
7253
Gene Symbols
TSHR,LGR3
Protein Name / Synonyms
Thyrotropin receptor (Thyroid-stimulating hormone receptor) (TSH-R)
Immunogen
Recombinant human TSH Receptor beta chain protein was used as the immunogen for this TSHR antibody.
IsotypeIgG2a
Purity
Protein G affinity chromatography
Concentration (lot specific)
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Recommended Applications
FACS: 0.5-1ug/10^6 cells in 0.1ml
IF: 1-2ug/ml
IHC (FFPE): 1-2ug/ml for 30 min at RT
Domain / Region / TerminusCytoplasmic, cell surface
Research AreaCancer, Autoimmune Disease, Endocrine
Shipping TypeBlue ice
Storage≤-20°C

Description

Description

Thyroid-stimulating hormone (TSH, also known as thyrotropin) is a glycoprotein involved in the control of thyroid structure and metabolism, which stimulates the release of the thyroid hormones. TSH is regulated by thyroid hormone (T3) and various retinoid compounds. TSH binds to the thyroid-stimulating hormone receptor (TSHR), which is cleaved into two subunits, A and B, and plays a major role in regulating thyroid function. The third cytoplasmic loop of TSHR has been identified as critical for its role in regulating inositol phosphate and cAMP formation. In Graves disease, an autoimmune disorder, TSHR is activated by autoantibodies, which may be stimulated by the cleavage of the A and B subunits.

Storage

Store the TSHR antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).
Expiration:
12 months from the date of shipment when stored properly.